Also, we found nominally significant associations in another 10 genes/loci, including KCND3, RAB3GAP1, UBXD2, MPDZ-NFIB, COL5A1, LOX, HGF, COL4A3, 13q33.3, and 19p12. In contrast, SNPs in 10 genes/loci that were reportedly associated with keratoconus were insignificant in our meta-analysis, including BHLHB2, BIRC8, IL1A, IL1B, KIF26B, LRRN1, PPP3CA, VSX1, 12p13.3 and 3q26.2. This evidence concerns the gene IL1B and keratoconus.