Among the 6 significant genes/loci for keratoconus, 5 were originally identified by GWAS, including FOXO1, FNDC3B, BANP-ZNF469, RXRA-COL5A1, and IMMP2L. In our meta-analysis involving data from the GWAS and independent replication studies, 3 genes/loci (i.e., FOXO1, FNDC3B, BANP-ZNF469) showed consistent effects with low heterogeneity across different study cohorts. The gene discussed is FOXO1; the disease is keratoconus.