In conclusion, we have prioritized 8 SNPs in 6 genes/loci as significant genetic markers for keratoconus in Whites, including FOXO1 rs2721051, RXRA-COL5A1 rs1536482, FNDC3B rs4894535, IMMP2L rs757219 and rs214884, and BANP-ZNF469 rs9938149, and COL4A4 rs2229813 and rs2228557. The gene discussed is COL4A4; the disease is keratoconus.