2016). This is important as research has shown AdipoR1 protein levels are decreased in the visceral adipose tissue of obese women (Rasmussen et al. 2006), downregulated in preinvasive ductal carcinoma in‐situ (Pfeiler et al. 2010) and LEP has been shown to down regulate AdipoR1 mRNA in breast cancer cells (Jarde et al. 2009). We found that overexpressing AdipoR1 was able to abolish the effects of the HFD‐CM on all cell‐cycle proteins measured (Figs 3 vs. 4) as well as overall cell‐cycle status (Fig. 5C vs. D). This evidence concerns the gene LEP and breast cancer.