In consequence, our results lead to identification and elucidation of signaling synergy of therapy‐resistant self‐sustaining TNBC and NSCLC cells based on GAS6 TAM‐dependent PDK‐RSK‐mTOR survival pathway and the AXLY779/EGFR/MET‐driven SRC‐mTOR pathway. The gene discussed is SRC; the disease is non-small cell lung carcinoma.