Indeed, these inflammatory mediators were shown to play a role in the mechanisms of seizures and epileptogenesis in animal models.6, 7, 8, 9, 10 In particular, the presence of IL‐1β and HMGB1 has been shown in brains of patients with various epileptic disorders, such as TLE and focal cortical dysplasia (FCD).6, 11, 12 In addition to the local formation of seizure‐inducing molecules in the CNS, molecules such as IL‐1β, TNF‐α, and IL‐6 also might enter the brain from the blood. The gene discussed is IL1B; the disease is Focal cortical dysplasia.