Interestingly, the osteosarcoma cell line HOS has been shown to express SOX1 but not SOX1-OT, while in contrast the neuroblastoma cell line SH-SY5Y showed signal for SOX1-OT but not SOX1. This observation indicates that SOX1 and SOX1-OT expression might be independent of each other in these cancer types, or there might be another regulatory mechanism for these two transcripts, which requires further exploration. The gene discussed is SOX1; the disease is cancer.