In ACPA-positive RA, these ORs (95% CI) were 1.36 (0.76–2.43), 2.83 (2.01–3.99), and 3.89 (1.50–10.09), respectively (p = 0.30, <0.01, and <0.01, respectively) and in ACPA-negative RA were 1.61 (0.65–3.96), 2.98 (1.76–5.05), and 3.24 (0.75–13.92), respectively (p = 0.30, <0.01, and 0.12, respectively). This evidence concerns the gene PRTN3 and rheumatoid arthritis.