Symptoms that indicate the possibility of a non-IgE-mediated allergy or an intolerance of a food protein are: (a) epigastric or abdominal pain, (b) gastroesophageal reflux symptoms (heartburn, retro-sternal discomfort, acid taste in the mouth, sometimes a mucousy form of vomiting), and (c) appetite disturbance (early satiety, picky appetite) (138, 139). The gene discussed is IGHE; the disease is allergic disease.