In HCC, HDACIs including SAHA and OSU-HDAC-42 have been described to trigger ACD based on both genetic- and pharmacological blocking experiments underscoring that SAHA- or OSU-HDAC-42-stimulated autophagy is required for the induction of cell death, as either silencing of ATG5 or 3-MA protected cells from the cytotoxicity of SAHA (32). This evidence concerns the gene ATG5 and hepatocellular carcinoma.