Furthermore, FGF2 and FGFR1 signaling in the prefrontal cortex is implicated in human depression and in rodent models of depression (Elsayed et al., 2012; Bachis et al., 2008; Kang et al., 2007; Gaughran et al., 2006; Evans et al., 2004). This evidence concerns the gene FGFR1 and major depressive disorder.