By applying MI model induced by left coronary artery ligation in rats, Cho et al. demonstrated elevated activated monocytes (CC chemokine receptor 2+ ED-1+) in peripheral blood, along with the infiltration of ED-1+ macrophages and the increment of nuclear p65 in the kidney of MI rats, suggesting the contribution of NF-κB-mediated inflammation in the development of type I CRS. Here, EDA is linked to myocardial infarction.