Hepatic fibrosis/hepatic stellate cell activation was also associated with adiponectin concentrations at week 4, whereas the LXR/retinoid-X-receptor (RXR) and FXR/RXR activation pathway were associated with cortisol at baseline correlating with CRP, SAP A, and sIL-2Rα. This evidence concerns the gene NR1H4 and Hepatic fibrosis.