Curcumin is also a polyphenolic compound that is well known as an inhibitor of DNA methyltransferase, beside its interaction together with microRNAs, reestablishes the balance between histone acetyl transferase and HDAC activity to selectively regulate the expression of genes concerned with human cancer (Fu and Kurzrock, 2010; Teiten et al., 2013). The gene discussed is HDAC9; the disease is cancer.