H2AX and Miyoshi myopathy: Treatment with API at the concentration of 50 μM for 24 h led to a significant increased of γ-H2AX in all MM cell lines (MM-F1, p = 0.001; MM-B1, p = 0.003; H-Meso-1, p = 0.03; #40a, p = 0.005) (Figure 3).