HSD17B2 and cancer: HSD17B2 catalyzes the oxidation of E2 back to the less potent E1, and expression of the corresponding gene HSD17B2 was increased in endometrial cancer (Lépine et al., 2010; Cornel et al., 2012; Sinreih et al., 2013), while there was no difference in expression of HSD17B2 among control and cancer cell lines (Hevir-Kene and Rižner, 2015).