Furthermore, pro-inflammatory cytokines IL-1β, IL-6, IL-8, and TNF-α were elevated both centrally (in the striatum and cerebrospinal fluid) and peripherally (in the plasma) in HD patients (Bjorkqvist et al., 2008; Chang et al., 2015; Rodrigues et al., 2016). Here, CXCL8 is linked to Huntington disease.