At univariate analysis (left panel), development of HCC was associated with older age, T2DM, and severe fibrosis (p < 0.001 for all), whereas among the genetic factors with PNPLA3 I148M (p < 0.001) and MBOAT7 T rs641738 T alleles (OR 2.18, 95% c.i. 1.30–3.63; p = 0.003). The gene discussed is PNPLA3; the disease is hepatocellular carcinoma.