PNPLA3 and hepatocellular carcinoma: After further adjustment for the presence of severe fibrosis stage F3-F4 (Model 2), the TM6SF2 E167K (p = 0.008) and MBOAT7 rs641738 T (OR per allele 1.65, 95% c.i. 1.08–2.55; p = 0.021; OR for T/T vs. C/C 2.73, 95% c.i. 1.17–6.51, p = 0.008) alleles remained significantly associated with HCC risk, whereas the effect of the PNPLA3 I148M variant was lost.