Only one SNP (rs3217869 in CCND2) was shown to be significantly associated with aggressive prostate cancer after the analysis in the three models (Additive model: P = 4.653 × 10−3, OR = 1.511, 95% CI = 1.135–2.010; Dominant model: P = 5.341 × 10−3, OR = 6.907, 95% CI = 1.773–26.900; Recessive model: P = 2.156 × 10−2, OR = 1.435, 95% CI = 1.055–1.954), Cochran–Armitage trend test (P = 5.188 × 10−3) and conditional analysis (Additive model: P = 7.263 × 10−3; Dominant model: P = 8.938 × 10−3; Recessive model: P = 2.629 × 10−2) (Table 2). The gene discussed is CCND2; the disease is prostate carcinoma.