CCND2 and cancer: With a number of genes15 such as EGFR, PDGF, GRB2, MET and cyclin D genes16 (CCND1, CCND2 and CCND3) involved, the RTK/ERK pathway regulates various biological processes including cellular signal transduction and crosstalk, cell proliferation, differentiation, survival and migration in normal and cancer development17, 18.