We found a significant association between EDS and high levels of NT-pro-BNP and cTnT, both of which are biomarkers of HF.27 28 NT-pro-BNP is produced in response to cardiac wall stress and is a strong predictor of HF.22 Troponin T is a plasma marker of myocyte necrosis, which has been positively associated with incident CVD, HF and all-cause mortality.29 Most notably men who reported EDS had a higher odds of having NT-pro-BNP of ≥400 pg/mL (the diagnostic threshold for HF). The gene discussed is NPPB; the disease is hydrops fetalis.