Our secondary objectives include determining the mechanisms of action of BTT1023 through in vitro assessment of sVAP-1 concentration, SSAO enzyme activity and immune cell function; evaluating the potential of a novel MRI-based assessment of liver fibrosis and biliary strictures for assessing therapeutic response in PSC; and assessing the use of sVAP-1/SSAO as a biomarker to monitor disease progression in PSC. The gene discussed is SNAP47; the disease is Hepatic fibrosis.