Previous studies described that DKK3 was expressed in various tumor endothelial cells9,10 and that overexpression of DKK3 did not affect proliferation and migration of endothelial colony-forming cell.10 Similarly, our data also showed that DKK3 within the cell after Adeno-DKK3 transduction did not induce cell migration, indicating that DKK3 may need to interact with its receptor(s) on the cell surface to exert its effects on cell movements. Here, DKK3 is linked to neoplasm.