The altered cellular phenotype that characterizes HGPS patients' cells, going along with progerin accumulation, and their premature senescence in culture (Goldman et al, 2004; Scaffidi & Misteli, 2005, 2008; Vidak & Foisner, 2016), led us to investigate the subcellular localization of progerin during prolonged fibroblast cell passages. The gene discussed is LMNA; the disease is Hutchinson-Gilford progeria syndrome.