SIRT6 and Hutchinson-Gilford progeria syndrome: Interestingly, we found an increase in the transcripts levels of genes involved in autophagy activation (p62, ATG4A, ATG4B, ATG4D, ATG3, ATG14, LLK1), proteasome subunits production (PSMC4, PSMB3), splicing (SRSF5), metalloprotease transcripts including MMP3 (whose levels are decreased in HGPS cells), growth factors (EGF, FGF17, FGF22), apoptosis inhibitors (BAG3, BFAR) as well as the improvement of other transcripts involved in inflammation (IkB, SIRT6) (Fig 5I).