It has not been determined whether SrcFK are ROS-sensitive in IPA, nor whether ROS- and/or SrcFK-mediated activation of RhoA/Rho-kinase occurs as part of the same signalling pathway in response to GPCR or hypoxia, but it is possible that SrcFK act as intermediaries between ROS and RhoA/Rho-kinase. Here, RHOA is linked to Ito hypomelanosis.