TP53BP1 and lung carcinoma: In a recent investigation of human lung carcinoma cell lines (A549) and V79 cells, the numbers of γH2AX and phosphorylated p53 binding protein 1 (53BP1) foci at 1 h and 12 h after exposure to 156.7-MeV to 182.8-MeV proton beam irradiation was lower for the irradiation target at the center of the SOBP than that for that at the distal end of the SOBP [15].