The node genes in the offspring of HF diet-fed dams were linked to changes in genes that are indicative of increased cancer risk (downregulation of ANKEF1, IGFBP6; upregulation of SEMA5B), increased resistance to cancer treatments (upregulation of EGR3, SLC26A3), poor cancer prognosis (upregulation of ID4, JAM3, TBX2), increased risk of metastasis (upregulation of GPCPD1) and impaired anticancer immune response (downregulation of ZBP1, upregulation of EGR3) (Additional file 8: reference table). The gene discussed is JAM3; the disease is hydrops fetalis.