In the HF group, genes identified as connected to the node genes were related to poor prognosis (SEMA5B, ID4, TBX2, GRHL3, DPF3), increased cellular proliferation and migration (GRHL3, PARP8, JAM3), and altered immune response (ZBP1, EGR3). The gene discussed is EGR3; the disease is hydrops fetalis.