The tumors with strong expression of vimentin from K14CreERβF/Fp53F/F mice developed with significantly reduced latency (330 days) and were less differentiated compared with the tumors with low vimentin expression from K14Crep53F/F mice (416 days, P < 0.001), suggesting that occurrence of EMT in the absence of ERβ may be associated with earlier onset of nonwell-differentiated breast cancers. This evidence concerns the gene ESR2 and breast carcinoma.