TP53 and acute lymphoblastic leukemia: In particular, significant results were obtained in the field of acute lymphoblastic leukemia (ALL), demonstrating the efficacy of the activation of P53 pathway and subsequent cell cycle block and apoptosis induction in aggressive childhood leukemia cells in vitro and in mice xenograft [84, 85] as well as reduction of cell viability, involving also autophagy, in adult ALL samples [86].