TP53 and lymphoma: Recently, the antitumor potential of the therapeutic combination based on the caspase-independent cell death and antibody-dependent cellular cytotoxicity triggered by obinutuzumab together with the caspase-dependent apoptosis mediated by idasanutlin has been evaluated in in vitro and in vivo models of lymphoma, reporting an enhanced P53 wild-type cell death without signs of reciprocal interference between the two pharmacological compounds [102].