In this line, Lu and colleagues have reported a P53-mediated apoptotic effect of MI-773 in a P53 wild-type neuroblastoma model with stabilizing effect on P53, both in vitro showing similar efficacy as RG7388 and Nutlin-3 and in an in vivo orthotropic model when the compound was used as single agent. This evidence concerns the gene TP53 and neuroblastoma.