TP53 and neoplasm: At the structural levels, the Nutlins are cis-imidazoline analogs discovered by Vassilev and colleagues in 2004 as compounds able to bind MDM2 in the P53-binding pocket with subsequent P53 accumulation, P53 pathways activation with the induction of cell cycle arrest, and apoptosis and growth inhibition in cancer cells and human tumor-xenografted nude mice [65].