In particular, the preclinical evaluation of the antitumor activity of MI-77301, also referred as SAR405838, revealed a good chemical stability of the compound and the capacity of inducing cell growth inhibition up to cell cycle arrest and/or apoptosis in a P53-dependent manner in several tumor cell lines (i.e., osteosarcoma, acute leukemia, prostate and colon cancer cells) [104]. Here, TP53 is linked to osteosarcoma.