In conclusion, our meta-analysis suggested that T allele of AMPD1 gene C34T polymorphism was correlated with LVEF (%), LVEDD (mm) and SBP (mmHg) of CVD, which plays a protective role in the recovery of ventricular remodeling and cardiac function, as well as blood pressure, but has no influences on the total survival rate and cardiac survival rate of HF patients. Here, AMPD1 is linked to hydrops fetalis.