Interestingly, BNC1 is also a putative ER receptor 1 (ESR1) target as ESR1 was bound in the proximal promoter of BNC1 in T-47D cell line (ENCODE data on UCSC genome browser), raising the possibility that BNC1 might also play a role in sexual dimorphism in liver cancer similar to FOXA1. The gene discussed is ESR1; the disease is liver cancer.