In support of the pathological role of ANKRD1, it was observed that Ankrd1 null mice did not display cardiac hypertrophy in response to phenylephrine while wild type mice showed significant hypertrophy due to ANKRD1-induced hypertrophic gene expression, indicating that ANKRD1 could be involved in accelerating the progression of hypertrophy [25]. The gene discussed is ANKRD1; the disease is cardiac hypertrophy.