However, it is interesting to note that in another study by Chen et al. [57], increased expression of ANKRD1 using recombinant adenoviral vectors carrying Ankrd1 in mice with transverse aortic constriction exacerbated pathological cardiac remodeling through activation of the calcineurin/nuclear factor of activated T-cells (NFAT) pathway, a signaling pathway known to have an important role in cardiac hypertrophy [58]. The gene discussed is ANKRD1; the disease is cardiac hypertrophy.