EXT1 is hypermethylated in leukemia (especially acute promyelotic leukemia and acute lymphoblastic leukemia) and nonmelanoma skin cancer in a screen of 454 primary tumors of different types and 79 human cancer cell lines, implying that epigenetic regulation of EXT1 is linked to oncogenesis [89]. This evidence concerns the gene EXT1 and acute lymphoblastic leukemia.