SULF1 and neoplasm: Wade et al. [58] reported that alterations in activity of the sulfatase enzymes SULF1 and SULF2 promote receptor tyrosine kinase signaling and progression in glioblastoma, and suggest that these alterations “are promising biomarkers for disease and therapeutic targets.” Not only can alterations occur between cancerous and non-cancerous cells, Fernandez-Vega et al. [59] reported that HS modifications may also be different in right-sided colorectal cancer (CRC), depending on the stage of the tumor.