As the EORTC QLQ-C30 questionnaire measures somatic and psychological symptoms, functional status and overall health of the individual it would be reasonable to assume a patient with lower scores is more likely to have worse mental and physical disease burden and demonstrate abnormalities at the biochemical level such as increased Interleukin-2 and Interleukin-6 levels, anemia and hypoalbuminemia, all which are known to contribute towards poor QOL in cancer patients [29,30,31,32,33,34]. The gene discussed is IL2; the disease is anemia (phenotype).