Moreover, Rajendran et al. [73] also demonstrated in hepatocellular carcinoma cell lines that γ-tocotrienol treatment could cause a down-regulation of the activity and expression of signal transducer and activator of transcription 3 (STAT3), a transcription factor shown to be activated by Wnt/β-catenin signalling [74], leading to the reduced expression of pro-proliferative genes. This evidence concerns the gene STAT3 and hepatocellular carcinoma.