A clinical trial of over 600 patients with mild-to-moderate AD who were taking an acetylcholinesterase inhibitor at the time of the study were assigned to a daily combination of memantine and/or 2000 IU alpha-tocopherol proved to slow cognitive decline based on the AD Cooperative Study/Activities of Daily Living (ADCS-ADL) Inventory [44,45]. The gene discussed is ACHE; the disease is Alzheimer disease.