TOMM40 and Alzheimer disease: It has been demonstrated that TOMM40 ‘523 affects the expression levels of APOE and TOMM40 mRNAs in the temporal and occipital cortexes of late onset AD patients and normal controls[50], and the effect of the TOMM40 poly-T variation on transcription regulation was recapitulated in a cell-based luciferase reporting system[51].