EGFR and cancer: Signal pathways, like β1-integrin and epidermal growth factor receptor (EGFR), function in a parallel way in traditional 2D culture which requires blocking both pathways at the same time in order to reduce cancer cell growth to below 20% of the control with no down-regulation of expression of either β1-integrin or EGFR, while in 3D they can be integrated in a reciprocal way in which inhibiting either of those two ways is enough to induce growth-arrest and down-regulation of both β1-integrin or EGFR [12, 18].