VEGFC and neoplasm: It has also been reported by others that high PDPN expression is associated with aggressive tumor behavior, poor prognosis and metastatic regulation through interaction with VEGF-C, suggesting that PDPN may be used as a potential prognostic biomarker for HNSCC.27 However, our in vitro studies did not reveal increased PDPN expression in HNSCC cells that resisted to MI (Supplementary Figure S8).