CXCL8 and head and neck squamous cell carcinoma: Stress and drug-induced IL-8 signaling conferred chemotherapeutic resistance to cancer cells.37 Serum and tumor IL-8 significantly affected the disease-free survival in patients with early stage HNSCC.38 Therefore, inhibiting the effects of IL-8 signaling in combination to chemoradiotherapy may be of significant therapeutic value.