Interestingly, low CAR2 protein expression has been associated with increased tumor size.26 In addition, the X tumors showed upregulation of human genes involved in metastasis, angiogenesis and epithelial mesenchymal transition, such as MMP2, MMP9, MMP13, MMP16, MMP28 and vimentin,15 while P tumors showed upregulation of human C–C Motif Chemokine Ligand 5 chemokine gene involved in CD8+ T lymphocytes recruitment associated with better clinical outcomes.49 This evidence concerns the gene MMP16 and neoplasm.