In our previous studies, JWA was identified as an important factor for chemotherapy-induced apoptosis.30, 42 JWA enhances cisplatin sensitivity in acquired cisplatin-resistant human GC cells (BGC823/DDP, SGC7901/DDP).9 The results led us to investigate whether JWA might have an effect on apoptosis in GC cells induced by TRAIL. This evidence concerns the gene ARL6IP5 and gastric cancer.