DVL1 and chronic pancreatitis: Phosphorylation of YAP by LATS1/2 on Ser127 is inhibitory and prevents nuclear localisation through cytoplasmic sequestration by proteins, such as 14-3-3 and DVL.43 YAP and TAZ nuclear localisation has been shown to be influenced by mechanical forces,20 and their expression is increased in patients with either PDAC or chronic pancreatitis.15, 44