CD248 has also been shown to have roles in angiogenesis, particularly in vessel regression during vascular patterning.11 CD248 has been described as a marker of pericytes associated with glioma vasculature,12 and is elevated in the stroma of many other tumours including colorectal, melanoma and glioblastoma.13, 14, 15 For these reasons, CD248 is actively being pursued as a cancer target with clinical trials underway.16 Here, CD248 is linked to central nervous system cancer.