AKT1 and malignant colon neoplasm: Colon cancer metastasis is also related to signalling pathways such as MAPK [146], ribosomal s6 kinase (RSK) via the extracellular signal-regulated kinase (ERK) [147], proto-oncogene tyrosine-protein kinase (Src) [148], and protein kinase B (Akt) [149,150].