SOCS3 and infection: Furthermore, RSV G protein regulates the early expression of miRNAs after infection or treatment of cells with purified RSV G protein, including let-7 family members [59,77], and let-7 miRNA expression is associated with decreased expression of multiple genes that may impact the expression of various cytokines and chemokines, including SOCS-3 [59], although the mechanism by which RSV G protein mediates miRNA regulation is not defined.