Since previous studies show that RSV G protein suppresses IFN induction of ISGs via enhanced expression of SOCS-1 and SOCS-3, and regulates miRNA expression during infection, the expression profiles of type I and III cytokines and microRNAs were examined; type III IFN and miRNAs let-7f and miR-24 were found to be altered between wildtype and RSV mutant virus infections. This evidence concerns the gene SOCS3 and viral infectious disease.