Based on the KEGG pathway enrichment-based clustering analysis, the peroxisome proliferator-activated receptor-γ (PPARγ) signaling pathway, metabolism of xenobiotics by CYP, glutathione metabolism, chemical carcinogenesis, retinol metabolism, drug metabolism, and alcoholism-related proteins increased in a dose-dependent manner in RIF-treated livers (Figure S3). This evidence concerns the gene PPARG and alcohol dependence.