These results can be associated with the decrease in adipogenesis related to mRNA expression of PPAR-γ, C/EBP-α, and aP2. In addition, VDAE supplementation lowered the expression of lipogenic genes, such as SREBP-1c, FAS, SCD-1, and CD36. Hence, VDAE exerts anti-obesity effects by suppressing adipogenesis and lipogenesis and can be considered a potent and useful functional food resource to prevent obesity. Here, FAS is linked to obesity due to melanocortin 4 receptor deficiency.