Of these, 7% had inherited metabolic disorders that included pyridoxine-dependent epilepsy caused by ALDH7A1mutation, pyridox(am)ine-5-phosphate oxidase (PNPO) deficiency, Menkes disease, cobalamin G deficiency, MTHFR deficiency, glucose transporter 1 deficiency, glycine encephalopathy, and pyruvate dehydrogenase complex (PDHC) deficiency [80]. This evidence concerns the gene PNPO and hyperinsulinemic hypoglycemia, familial, 4.