Disorders of autophagy include Vici syndrome, β-propeller protein-associated neurodegeneration due to mutations in WDR45 (WD repeat domain 45) gene, SNX14 (Sorting Nexin 14)-associated autosomal recessive cerebellar ataxia and intellectual disability syndrome, and variants of hereditary spastic paraplegia. Here, WDR45 is linked to hereditary spastic paraplegia.