Further detailed study, such as the functional assay of sphere formation under the knockdown of ALDH1A1 or ALDH3A1, is needed to define the molecular mechanisms involved in the function of NRF2 and its effectors, including members of ALDHs in pancreatic cancer cells in relevance with drug resistance and cancer cell stemness. This evidence concerns the gene ALDH3A1 and familial pancreatic carcinoma.