Of the proteins whose functions are modulated by HDACs, the p53 (tumor protein 53), RUNX3 (Core binding factor α3 subunit), STAT3 (Signal transduction and activation of transcription 3), β-catenin, estrogen receptor, Myc (Avian myelocytomatosis viral oncogene homolog), EKLF (Erythroid Kruppel-like factor), GATA family (GATA-binding factors), HIF-1α (Hypoxia-inducible factor 1α), MyoD (Myogenic regulatory factor), NF-κB (Nuclear factor κB) or Foxp3 (Forkhead box P3 protein), are the most important in cancer (for review, see [19]). This evidence concerns the gene TP53 and cancer.