HDAC9 and cancer: On the contrary, Lin et al. found that HDAC inhibition resulted in the development of metastatic phenotype including increasing of matrix metalloproteinases (MMPs) expression in some cancer cell lines (liver (SNU-398, Huh6, HepG2, Hep3B, Huh7, PLC5, HCC36, TONG, HA59T, Sk-hep-1, HA22T, and Malhavu), lung (H358, H1437, H661, H226Br, H1299, CL1-3, CL1-0, H23, H928, and A549), gastric (NUGC, SC-M1, AZ521, AGS, and HR), and breast (MDA-231, Hs578T, and MCF-7) cancer) [117].