CB-839 had a potent effect on the proliferation of multiple PDAC cell lines, including cells derived from primary tumours of a LSL-KrasG12D; p53L/+, Pdx1-Cre mouse model of PDAC (MPADC-4)24, with IC50s in the low nanomolar range (Fig. 1b, c). The gene discussed is PDX1; the disease is neoplasm.