Overexpressedproteins in tMSCs isolated from low grade gliomas were mitochondrial manganese-containingsuperoxide dismutase (Mn-SOD), 40S ribosomal protein SA, and GTP-binding nuclear protein,while in tMSCs isolated from high grade gliomas, cathepsin B, endoplasmin, ezrin, peroxiredoxin1, and pyruvate kinase (PK) were found to be significantly overexpressed. Here, SOD2 is linked to central nervous system cancer.