Overexpressedproteins in tMSCs isolated from low grade gliomas were mitochondrial manganese-containingsuperoxide dismutase (Mn-SOD), 40S ribosomal protein SA, and GTP-binding nuclear protein,while in tMSCs isolated from high grade gliomas, cathepsin B, endoplasmin, ezrin, peroxiredoxin1, and pyruvate kinase (PK) were found to be significantly overexpressed. The gene discussed is HSP90B1; the disease is central nervous system cancer.