Among the enriched commensals in response to HSCBs, Escherichia coli was reported to instigate chronic colitis and Th17 response [40,41,42,43], Ruminococcus was shown to drive provocative IL-17 expression in mesenteric lymph nodes [44], and Mucispirillum elicited T cells-dependent IgA response, similar to segmented filamentous bacterium [45]. Here, IL17A is linked to Chronic colitis.