KISS1 and Infertility: We observed the lowest levels of KP in females who had unexplained infertility which is consistent with the hypothesis that mutation in the 5ˊ untranslated region (UTR) (deletion, rs5780218) in Exon 1 of KISS1 may disrupt HPO axis, reduce KP levels and likely to be one of the reasons of unexplained infertility (16).